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Rimonabant is active substance of Slimona
Rimonabant – is the first representative of a new class of drugs – cannabinoid receptor type I (CB1). Rimonabant modulates hyperactive system of endocannabinoid by selective binding of central and peripheral CB1 receptors. It is obtained the research results, in respect of reduction of severity of risk factors for cardiovascular diseases as a result of decrease the amount of abdominal fat and appropriate improvement of metabolic parameters that go beyond the expected, based on weight loss.
Obesity is the biggest public health problem and one of the most frequent causes of death worldwide, mainly due to cardiovascular disease. Obesity is usually determined by body mass index (BMI), however recent studies have shown that visceral (abdominal) obesity (its degree directly correlates with the size of waist circumference) is the best factor for predicting the risk of acute coronary syndrome than body weight or BMI. In 44% of adult US population, waist circumference exceeds the risk level (40 inches for men and 35 inches for women). Visceral type of obesity is associated with the causes of metabolic risk factors, such as dyslipidemia or insulin resistance that can lead to diabetes, myocardial infarction, stroke and other cardiovascular diseases. Reduction in the degree of visceral obesity degree is a recognized priority for preventing cardiovascular disease.
Cardiovascular risk factors, associated with obesity became more pronounced. Excessive amount of abdominal fat is increasingly recognized as one of the most informative precursor of future cardiovascular complications. Results of two-year Rio-North America study confirm that Slimona is an innovative and promising means for long-term correction of obesity and associated cardiovascular risk factors in patients with abdominal obesity.
Slimona and endocannabinoid system
Endocannabinoid system is a recently discovered physiological system in the body which, experts believe, plays an important role in the central and peripheral regulation of energy balance, metabolism of glucose and lipids, as well as control of tobacco addiction.
CB1 receptors are found in the brain and in peripheral body tissues, such as adipocytes that are associated with the metabolism of lipids and glucose. Consumption of excessive amounts of food or chronic use of tobacco leads to hyperresponsiveness of endocannabinoid system. This can launch the mechanism of increase in food intake and fat accumulation or in the case of smoking, sustained tobacco addiction.